(1888) Arndt first stated that "weak stimuli slightly accelerate the vital activity, medium-strong stimuli raise it, strong ones suppress it and very strong ones halt it"". Schultz published various examples of yeast growth stimulation by using subtoxic concentrations of various poisons such as iodine, bromine, arsenious acid etc.
The name "Avogadro's Number" is just an honorary name attached to the calculated value of the number of atoms, molecules, etc. in a gram mole of any chemical substance. That means that there is a limit of dilution such that when you go beyond his number for adding a neutral substance like alcohol there can be no molecule of physical remedy left. Since x bracket remedies are in direct and clear relationship to the decimal numbering system, we can see that going beyond a 23x remedy means that you shouldn't have any physical substance left at all in the vial. Going beyond a 11c is the same thing.
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(1943) Hormology is the study of excitation. Small and large doses induce opposite physiologic results. The toxic action of a substance becomes a stimulating agent at a lower concentration. Conversely, the administration of low doses of a poison to an organism increases the resistance towards that poison. The famous king Mithridate, using small daily doses of various poisons, could not be killed by poison and eventually died by a sword-thrust.